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Article

Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas.

Cancer prevention research (Philadelphia, Pa.) - 1 Aug 2008

Tang Ximing, Varella-Garcia Marileila, Xavier Ana C, Massarelli Erminia, Ozburn Natalie, Moran Cesar, Wistuba Ignacio I

Abstract excerpt

To identify the characteristics and sequence of epidermal growth factor receptor (EGFR) abnormalities relevant to the pathogenesis and progression of lung adenocarcinoma, we performed a precise mapping analysis of EGFR mutation, gene copy number, and total and phosphorylated EGFR protein expression for the same tissue sites. We examined normal bronchial and bronchiolar epithelium (NBE) and tumor tissues obtained...

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Source

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Identifiers

PMID: 19138956
DOI: 10.1158/1940-6207.CAPR-08-0032
PMCID: PMC3369271

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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