Article
Abnormalities of epidermal growth factor receptor in lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas: tyrosine kinase domain mutations are not rare in tumors with an adenocarcinoma component.
Cancer - 15 Feb 2007
Ohtsuka Kouki, Ohnishi Hiroaki, Fujiwara Masachika, Kishino Tomonori, Matsushima Satsuki, Furuyashiki Go, Takei Hidefumi, Koshiishi Yoshihiko, Goya Tomoyuki, Watanabe Takashi
Abstract excerpt
BACKGROUND: Tyrosine kinase domain (TKD) gene mutations of the epidermal growth factor receptor gene (EGFR) have proven to be clinically significant in nonsmall-cell lung cancer (NSCLC), particularly in adenocarcinoma. However, TKD mutations together with deletion mutations in the extracellular domain of EGFR (EGFRvIII) have not been fully investigated in NSCLC except for adenocarcinoma. The present study sought...
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