Differential regulation of adenovirus late transcriptional units by the products of early region.

Abstract excerpt

Normal accumulation of adenoviral late mRNAs derived from the major late promoter, is mediated independently by either the ORF 6 or the ORF 3 product of E4. We have examined the role of E4 products in the expression of three late messages that are derived from outside the major late transcriptional unit: polypeptide IX mRNA, IVa2 mRNA, and messages from the E2 late promoter. We conclude that the late RNA...

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