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Article

Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice

31 Jul 2007

Abstract excerpt

Parkinson's disease (PD) may be caused by a complex interaction of environmental insults and genetic susceptibilities. Previous studies of DJ-1-deficient mice have noted dopaminergic dysfunction mainly in older mice. To simulate the interaction of genetic factors and environmental factors, we treated DJ-1-deficient mice with paraquat. Even in relatively young mice, this combination produced dopamine loss and...

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PMID: 17823202
DOI: 10.1093/hmg/ddm249

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