CG-4, a new bipotential glial cell line from rat brain, is capable of differentiating in vitro into either mature oligodendrocytes or type-2 astrocytes.

doi:10.1002/jnr.490310125

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Article

CG-4, a new bipotential glial cell line from rat brain, is capable of differentiating in vitro into either mature oligodendrocytes or type-2 astrocytes.

Journal of neuroscience research - 1 Jan 1992

Louis J C, Magal E, Muir D, Manthorpe M, Varon S

Abstract excerpt

We have established a permanent cell line (CG-4) of rat central nervous system glial precursors from primary cultures of bipotential oligodendrocyte-type 2-astrocyte (O-2A) progenitor cells, which were kept proliferating with the mitogen(s) secreted by the neuronal B104 cell line. The CG-4 cells have a normal karyotype and display the properties of normal O-2A cells. CG-4 cells can be propagated in serum-free...

Topics

Animals
Animals, Newborn
Astrocytes
Cell Differentiation
Cell Division
Cell Line
Cerebral Cortex
Culture Media
Growth Substances
Humans
Karyotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuroblastoma

Oligodendroglia

Phenotype

Rats

Rats, Inbred Strains

Swine

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1613821
DOI: 10.1002/jnr.490310125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1613821-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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