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Article

O-2A glial progenitors from mature brain respond to CNS neuronal cell line-derived growth factors.

Journal of neuroscience research - 1 Apr 1991

Hunter S F, Bottenstein J E

Abstract excerpt

During development, myelin-forming oligodendrocytes and type 2 astrocytes are believed to arise from bipotential (O-2A) glial progenitors. Previously we found that conditioned medium (CM) from the B104 rat CNS neuronal cell line promotes growth of neonatal rat O-2A progenitors in serum-free culture conditions with subsequent increases in differentiated progeny. We now report that O-2A progenitors are present in...

Topics

Animals
Autoradiography
Brain
Cell Line
Cell Movement
Cells, Cultured
Central Nervous System
Culture Media
Fluorescent Antibody Technique
Male
Nerve Growth Factors
Neuroglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodendroglia

Phenotype

Rats

Rats, Inbred Strains

Stem Cells

Source

Identifiers

PMID: 1870158
DOI: 10.1002/jnr.490280415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1870158-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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O-2A glial progenitors from mature brain respond to CNS neuronal cell line-derived growth factors.PMID 1870158Read ↗

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