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The relation between NOD2/CARD15 mutations and the prevalence and phenotypic heterogeneity of Crohn's disease: lessons from the Israeli Arab Crohn's disease cohort.

Digestive diseases and sciences - 1 Sept 2005

Karban Amir, Atia Oren, Leitersdorf Eran, Shahbari Azmi, Sbeit Wisam, Ackerman Zvi, Mualem Rawia, Levine Arie, Nesher Shula, Safadi Rifaat, Eliakim Rami

Abstract excerpt

The prevalence of Crohn's disease depends on geographic location and racial background. Arg702Trp, Gly908Arg, and Leu1007fsinsC mutations in the NOD2/CARD15 gene are associated with Crohn's disease in Caucasians. The mutation rate among Israeli Jewish patients is 27%-41%. The prevalence of Crohn's disease is much lower in the Israeli Arab compared to the Israeli Jewish population. We studied the NOD2/CARD15...

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Identifiers

PMID: 16133971
DOI: 10.1007/s10620-005-2917-x

Genes

NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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