Article
NOD2/CARD15: geographic differences in the Spanish population and clinical applications in Crohn's disease.
Revista espanola de enfermedades digestivas - 1 May 2010
Barreiro-de-Acosta M, Mendoza J L, Lana R, Domínguez-Muñoz J E, Díaz-Rubio M
Abstract excerpt
Crohn's disease (CD) is a genetically complex disease in which both genetic susceptibility and environmental factors play key roles in the development of the disorder. NOD2/CARD15 mutations are associated with CD. NOD2 encodes for a protein that is an intracellular receptor for a bacterial product (muramyl dipeptide), though the exact functional consequences of these mutations remain the subject of debate....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.