Article

Temperature-responsive structural reversibility of FGF21 and structure-based design of its variant with enhanced potency

2021-11-17

Abstract excerpt

Fibroblast growth factor 21 (FGF21) has pharmaceutical potential against obesity-related metabolic disorders, including non-alcoholic fatty liver disease. Since thermal stability is a desirable factor for therapeutic proteins, we investigated the thermal behavior of human FGF21. FGF21 remained soluble after heating; thus, we examined its temperature-induced structural changes using circular dichroism (CD). FGF21 s...

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Literature Corpus work: 799c1ee1-3156-52e8-9554-6c82a4e57d5c
DOI: 10.1101/2021.11.16.468794

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