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Article

Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor.

Scientific reports - 2 Aug 2021

Agrawal Shilpi, Govind Kumar Vivek, Gundampati Ravi Kumar, Moradi Mahmoud, Kumar Thallapuranam Krishnaswamy Suresh

Abstract excerpt

Human acidic fibroblast growth factor (hFGF1) is an all beta-sheet protein that is involved in the regulation of key cellular processes including cell proliferation and wound healing. hFGF1 is known to aggregate when subjected to thermal unfolding. In this study, we investigate the equilibrium unfolding of hFGF1 using a wide array of biophysical and biochemical techniques. Systematic analyses of the thermal and...

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Identifiers

PMID: 34341408
DOI: 10.1038/s41598-021-95050-2
PMCID: PMC8329156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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