Article
Influence of genetic polymorphisms of styrene-metabolizing enzymes and smoking habits on levels of urinary metabolites after occupational exposure to styrene.
Toxicology letters - 30 Dec 2005
Ma Mingyue, Umemura Tomohiro, Mori Yuko, Gong Yingyan, Saijo Yasuaki, Sata Fumihiro, Kawai Toshio, Kishi Reiko
Abstract excerpt
Here we evaluate the influence of individual genetic polymorphisms of drug-metabolizing enzymes as well as body mass index (BMI) and lifestyle (smoking, alcohol consumption) on urinary metabolites after occupational exposure to styrene. Seventy-three workers exposed to styrene in a reinforced-plastics workplace were studied. The personal styrene exposure in the air and the urinary styrene metabolites mandelic...
Topics
- Adult
- Alcohol Drinking
- Aryl Hydrocarbon Hydroxylases
- Body Mass Index
- Cytochrome P-450 CYP2B6
- Cytochrome P-450 CYP2E1
- Epoxide Hydrolases
- Genotype
- Glutathione S-Transferase pi
- Glutathione Transferase
- Glyoxylates
- Humans
- Male