Article
GSTM1 polymorphism and styrene metabolism: insights from an acute accidental exposure.
Toxicology letters - 5 Aug 2002
Manini Paola, De Palma Giuseppe, Mozzoni Paola, Andreoli Roberta, Poli Diana, Bergamaschi Enrico, Franchini Innocente, Mutti Antonio
Abstract excerpt
Two workers were accidentally exposed to unusually high styrene concentrations (>1000 ppm) for about 30 min. In addition to the main styrene metabolites, mandelic acid (MA) and phenylglyoxylic acid (PGA), other minor metabolites, including specific mercapturic acids, (R,R)- and (S,R)-N-acetyl-S-(1-phenyl-2-hydroxyethyl)-L-cysteine [(R,R)-M1 and (S,R)-M1] and (R,R)- and...
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