Article
Non-CpG cytosine methylation of p53 exon 5 in non-small cell lung carcinoma.
Lung cancer (Amsterdam, Netherlands) - 1 Dec 2005
Kouidou Sofia, Agidou Tania, Kyrkou Athena, Andreou Alexandra, Katopodi Theodora, Georgiou Elisavet, Krikelis Dimitris, Dimitriadou Afroditi, Spanos Panagiotis, Tsilikas Christos, Destouni Hara, Tzimagiorgis Georgios
Abstract excerpt
Non-CpG methylation of cytosine residues, a mechanism associated with regulation of gene expression, has not been investigated in human cancer until now. Analysis of the p53 exon 5 mutation spectrum in mutation databases for lung cancer reveals frequent GC>AT transitions, several of which occur at non-CpG sequences. To investigate the involvement of cytosine methylation in this mutagenesis process, we analyzed...
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