Article
Methylation, mutation and cancer.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jan 1992
Jones P A, Rideout W M, Shen J C, Spruck C H, Tsai Y C
Abstract excerpt
The fifth base in human DNA, 5-methylcytosine, is inherently mutagenic. This has led to marked changes in the distribution of the CpG methyl acceptor site and an 80% depletion in its frequency of occurrence in vertebrate DNA. The coding regions of many genes contain CpGs which are methylated in sperm and serve as hot spots for mutation in human genetic diseases. Fully 30-40% of all human germline point mutations...
Topics
- 5-Methylcytosine
- Animals
- Cell Transformation, Neoplastic
- Cytosine
- DNA
- DNA, Neoplasm
- Deamination
- Female
- Genes, p53
- Genetic Diseases, Inborn
- Humans
- Male