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Article

NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2006

Ishiguro Hiroki, Liu Qing-Rong, Gong Jian-Ping, Hall Frank Scott, Ujike Hiroshi, Morales Marisela, Sakurai Takeshi, Grumet Martin, Uhl George R

Abstract excerpt

Several lines of evidence support roles for the cell adhesion molecule NrCAM in addictions. Fine mapping within a chromosome 7 region that contains previously linked and associated genomic markers identifies NrCAM haplotypes that are associated with substance abuse vulnerabilities in four samples of abusers and controls. Differential display identifies NrCAM as a drug regulated gene. NrCAM is expressed in neurons...

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PMID: 16123759
DOI: 10.1038/sj.npp.1300855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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