Article
Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2006
Liu Qing-Rong, Drgon Tomas, Johnson Catherine, Walther Donna, Hess Judith, Uhl George R
Abstract excerpt
Addictions are substantially heritable complex disorders. We now report whole genome association studies that identify 89 genes likely to contain variants that contribute to addiction vulnerability, using previously- and newly-validated microarray based pooling assays. Each gene contains clustered single nucleotide polymorphisms (SNPs) that display significant allele frequency differences between abusers and...
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