Article
Primary sequence independence for prion formation.
Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2005
Ross Eric D, Edskes Herman K, Terry Michael J, Wickner Reed B
Abstract excerpt
Many proteins can adopt self-propagating beta-sheet-rich structures, termed amyloid fibrils. The [URE3] and [PSI+] prions of Saccharomyces cerevisiae are infectious amyloid forms of the proteins Ure2p and Sup35p, respectively. Ure2p forms prions primarily as a result of its sequence composition, as versions of Ure2p with the prion domain amino acids shuffled are still able to form prions. Here we show that prion...
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