Article
Prions of yeast as heritable amyloidoses.
Journal of structural biology - 1 Jun 2000
Wickner R B, Taylor K L, Edskes H K, Maddelein M L, Moriyama H, Roberts B T
Abstract excerpt
Two infectious proteins (prions) of Saccharomyces cerevisiae have been identified by their unusual genetic properties: (1) reversible curability, (2) de novo induction of the infectious prion form by overproduction of the protein, and (3) similar phenotype of the prion and mutation in the chromosomal gene encoding the protein. [URE3] is an altered infectious form of the Ure2 protein, a regulator of nitrogen...
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