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Article

Two prion-inducing regions of Ure2p are nonoverlapping.

Molecular and cellular biology - 1 Jun 1999

Maddelein M L, Wickner R B

Abstract excerpt

Ure2p of Saccharomyces cerevisiae normally functions in blocking utilization of a poor nitrogen source when a good nitrogen source is available. The non-Mendelian genetic element [URE3] is a prion (infectious protein) form of Ure2p, so that overexpression of Ure2p induces the de novo appearance of infectious [URE3]. Earlier studies defined a prion domain comprising Ure2p residues 1 to 64 and a nitrogen regulation...

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Identifiers

PMID: 10330190
DOI: 10.1128/MCB.19.6.4516
PMCID: PMC104409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two prion-inducing regions of Ure2p are nonoverlapping.PMID 10330190Read ↗

Prions of yeast as heritable amyloidoses.Semantic proximity Read ↗

The [URE3] yeast prion: from genetics to biochemistry.Semantic proximity Read ↗

The yeast prion [URE3] can be greatly induced by a functional mutated URE2 allele.Semantic proximity Read ↗

Mutations Outside the Ure2 Amyloid-Forming Region Disrupt [URE3] Prion Propagation and Alter Interactions with Protein Quality Control Factors.Semantic proximity Read ↗

A promiscuous prion: efficient induction of [URE3] prion formation by heterologous prion domains.Semantic proximity Read ↗

Internal initiation drives the synthesis of Ure2 protein lacking the prion domain and affects [URE3] propagation in yeast cells.Semantic proximity Read ↗

Hermes Transposon Mutagenesis Shows [URE3] Prion Pathology Prevented by a Ubiquitin-Targeting Protein: Evidence for Carbon/Nitrogen Assimilation Cross Talk and a Second Function for Ure2p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Innate immunity to prions: anti-prion systems turn a tsunami of prions into a slow drip.Semantic proximity Read ↗

How to find a prion: [URE3], [PSI+] and [beta].Semantic proximity Read ↗

Prions affect the appearance of other prions: the story of [PIN(+)].Semantic proximity Read ↗

In vitro analysis of SpUre2p, a prion-related protein, exemplifies the relationship between amyloid and prion.Semantic proximity Read ↗

[URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae.Semantic proximity Read ↗

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