Article
Mutations Outside the Ure2 Amyloid-Forming Region Disrupt [URE3] Prion Propagation and Alter Interactions with Protein Quality Control Factors.
Molecular and cellular biology - 13 Oct 2020
Kumar Shailesh, Dine Elliot A, Paddock Ethan, Steinberg Danielle N, Greene Lois E, Masison Daniel C
Abstract excerpt
The yeast prion [URE3] propagates as a misfolded amyloid form of the Ure2 protein. Propagation of amyloid-based yeast prions requires protein quality control (PQC) factors, and altering PQC abundance or activity can cure cells of prions. Yeast antiprion systems composed of PQC factors act at normal abundance to restrict establishment of the majority of prion variants that arise de novo While these systems are...
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