Article
Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic reticulum store depletion.
The Journal of biological chemistry - 4 Nov 2005
Hurne Alanna M, O'Brien Jennifer J, Wingrove Douglas, Cherednichenko Gennady, Allen Paul D, Beam Kurt G, Pessah Isaac N
Abstract excerpt
Bi-directional signaling between ryanodine receptor type 1 (RyR1) and dihydropyridine receptor (DHPR) in skeletal muscle serves as a prominent example of conformational coupling. Evidence for a physiological mechanism that upon depolarization of myotubes tightly couples three calcium channels, DHPR, RyR1, and a Ca(2+) entry channel with SOCC-like properties, has recently been presented. This form of...
Topics
- Animals
- Calcium
- Cations
- Cysteine
- Electrophysiology
- Mice
- Muscle Fibers, Skeletal
- Muscle, Skeletal
- Mutagenesis, Site-Directed
- Mutation
- Rabbits
- Ryanodine Receptor Calcium Release Channel
- Sarcoplasmic Reticulum