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Article

Bottleneck effect on genetic variance. A theoretical investigation of the role of dominance.

Genetics - 1 Sept 1998

Wang J, Caballero A, Keightley P D, Hill W G

Abstract excerpt

The phenomenon that the genetic variance of fitness components increase following a bottleneck or inbreeding is supported by a growing number of experiments and is explained theoretically by either dominance or epistasis. In this article, diffusion approximations under the infinite sites model are used to quantify the effect of dominance, using data on viability in Drosophila melanogaster. The model is based on...

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Identifiers

PMID: 9725859
DOI: 10.1093/genetics/150.1.435
PMCID: PMC1460318

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