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Article

Two steps forward, one step back: the pleiotropic effects of favoured alleles.

Proceedings. Biological sciences - 7 Apr 2004

Otto Sarah P

Abstract excerpt

Pleiotropy is one of the most commonly observed attributes of genes. Yet the extent and influence of pleiotropy have been underexplored in population genetics models. In this paper, I quantify the extent to which pleiotropy inhibits the spread of alleles in response to directional selection on a focal trait. Under the assumption that pleiotropic effects are extensive and deleterious, the fraction of alleles that...

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Identifiers

PMID: 15209104
DOI: 10.1098/rspb.2003.2635
PMCID: PMC1691650

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Source receipt: pubmed, retrieved 7 Sept 2026.

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