Regulation of early signaling and gene expression in the α-particle and bystander response of IMR-90 human fibroblasts

Abstract excerpt

BACKGROUND: The existence of a radiation bystander effect, in which non-irradiated cells respond to signals from irradiated cells, is well established. To understand early signaling and gene regulation in bystander cells, we used a bio-informatics approach, measuring global gene expression at 30 minutes and signaling pathways between 30 minutes and 4 hours after exposure to alpha-particles in IMR-90 fibroblasts....

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