Article
Association of HLA alleles with Plasmodium falciparum severity in Malian children.
Tissue antigens - 1 Jun 2011
Lyke K E, Fernández-Viňa M A, Cao K, Hollenbach J, Coulibaly D, Kone A K, Guindo A, Burdett L A, Hartzman R J, Wahl A R, Hildebrand W H, Doumbo O K, Plowe C V, Sztein M B
Abstract excerpt
Pre-erythrocytic immunity to Plasmodium falciparum malaria is likely to be mediated by T-cell recognition of malaria epitopes presented on infected host cells via class I and II major histocompatibility complex (MHC) antigens. To test for associations of human leukocyte antigen (HLA) alleles with disease severity, we performed high-resolution typing of HLA class I and II loci and compared the distributions of...
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