Article
Initial experiences and future directions for transgenic mouse mutation assays.
Mutation research - 1 Jun 1994
Suzuki T, Hayashi M, Sofuni T
Abstract excerpt
Transgenic mice have introduced new possibilities in the field of mutation research and safety testing. Using lacZ transgenic mice (Muta Mouse), we have combined the peripheral blood micronucleus assay with the transgenic mouse mutation assay, enabling the concomitant detection of gene mutations and micronucleus induction in vivo in the same animals (Suzuki et al., 1993). Several mutagens, i.e., mitomycin C...
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