Initial experiences and future directions for transgenic mouse mutation assays.

doi:10.1016/0027-5107(94)90259-3

Back to search

Article

Initial experiences and future directions for transgenic mouse mutation assays.

Mutation research - 1 Jun 1994

Suzuki T, Hayashi M, Sofuni T

Abstract excerpt

Transgenic mice have introduced new possibilities in the field of mutation research and safety testing. Using lacZ transgenic mice (Muta Mouse), we have combined the peripheral blood micronucleus assay with the transgenic mouse mutation assay, enabling the concomitant detection of gene mutations...

Topics

Animals
Bone Marrow
Bone Marrow Cells
Color
DNA Transposable Elements
Diethylnitrosamine
Ethyl Methanesulfonate
Ethylnitrosourea
Lac Operon
Liver
Male
Mice
Mice, Transgenic
Micronucleus Tests
Mitomycin
Models, Genetic
Mutagenesis, Site-Directed
Mutagenicity Tests

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.