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Article

Myostatin auto‐regulates its expression by feedback loop through Smad7 dependent mechanism

18 Aug 2005

Abstract excerpt

Myostatin, a secreted growth factor, is a member of the TGF-beta superfamily and an inhibitor of myogenesis. Previously, we have shown that myostatin gene expression is regulated at the level of transcription and that myostatin is a downstream target gene of MyoD. Here we show that myostatin gene expression is auto-regulated by a negative feedback mechanism. Northern blot analysis indicated that there are...

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PMID: 16110474
DOI: 10.1002/jcp.20477

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