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Article

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

29 Sept 2003

Abstract excerpt

Myostatin, a transforming growth factor beta (TGF-beta) family member, is a potent negative regulator of skeletal muscle growth. In this study we characterized the myostatin signal transduction pathway and examined its effect on bone morphogenetic protein (BMP)-induced adipogenesis. While both BMP7 and BMP2 activated transcription from the BMP-responsive I-BRE-Lux reporter and induced adipogenic differentiation,...

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PMID: 14517293
DOI: 10.1128/mcb.23.20.7230-7242.2003

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