Article
Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of α-globin transgene variegation.
Genomics - 1 Feb 2015
Sorolla Anabel, Tallack Michael R, Oey Harald, Harten Sarah K, Daxinger Lucia Clemens-, Magor Graham W, Combes Alex N, Ilsley Melissa, Whitelaw Emma, Perkins Andrew C
Abstract excerpt
Position-effect variegation of transgene expression is sensitive to the chromatin state. We previously reported a forward genetic screen in mice carrying a variegated α-globin GFP transgene to find novel genes encoding epigenetic regulators. We named the phenovariant strains "Mommes" for modifiers of murine metastable epialleles. Here we report positional cloning of mutations in two Momme strains which result in...
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