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Article

Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells

1 Feb 2002

Abstract excerpt

The PR-A and PR-B isoforms of progesterone receptors (PR) have different physiological functions, and their ratio varies widely in breast cancers. To determine whether the two PR regulate different genes, we used human breast cancer cell lines engineered to express one or the other isoform. Cells were treated with progesterone in triplicate, time-separated experiments, allowing statistical analyses of microarray...

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PMID: 11717311
DOI: 10.1074/jbc.m110090200

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