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HSD11B2 CA-repeat and sodium balance.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jul 2013

Mune Tomoatsu, Morita Hiroyuki, Takada Nobuki, Yamamoto Yoritsuna, Isomura Yukinori, Suwa Tetsuya, Takeda Jun, White Perrin C, Kaku Kohei

Abstract excerpt

Type 2 11β-hydroxysteroid dehydrogenase encoded by the HSD11B2 gene converts cortisol to inactive cortisone and thus protects the mineralocorticoid receptor from cortisol exposure. Impaired activity of this enzyme leads to mineralocorticoid excess, suggesting HSD11B2 as a candidate locus for pati...

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PMID: 23446772
DOI: 10.1038/hr.2013.13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23446772-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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