Article
Pro-fibrotic polymorphisms predictive of advanced liver fibrosis in the severely obese.
Journal of hepatology - 1 Dec 2003
Dixon John B, Bhathal Prithi S, Jonsson Julie R, Dixon Andrew F, Powell Elizabeth E, O'Brien Paul E
Abstract excerpt
BACKGROUND/AIMS: Insulin resistance and systemic hypertension are predictors of advanced fibrosis in obese patients with non-alcoholic fatty liver disease (NAFLD). Genetic factors may also be important. We hypothesize that high angiotensinogen (AT) and transforming growth factor-beta1 (TGF-beta1) producing genotypes increase the risk of liver fibrosis in obese subjects with NAFLD. METHODS: One hundred and five of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.