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Article

Host genetic factors influence disease progression in chronic hepatitis C

1 Apr 2000

Abstract excerpt

Progressive hepatic fibrosis and cirrhosis develops in 20% to 30% of patients with chronic hepatitis C virus (HCV). We propose that host genetic factors influencing fibrogenesis may account for some of the variability in progression of this disease. In progressive fibrosis of other organs, particularly heart and kidney, production of the profibrogenic cytokine, transforming growth factor beta1 (TGF-beta1), may be...

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PMID: 10733535
DOI: 10.1053/he.2000.6253

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