Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv.

The EMBO journal - 7 Sept 2005

Doumont Gilles, Martoriati Alain, Beekman Chantal, Bogaerts Sven, Mee Patrick J, Bureau Fabrice, Colombo Emanuela, Alcalay Myriam, Bellefroid Eric, Marchesi Francesco, Scanziani Eugenio, Pelicci Pier Giuseppe, Marine Jean-Christophe

Abstract excerpt

In response to DNA damage, p53 activates a G1 cell cycle checkpoint, in part through induction of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Here we report the identification of a new direct p53 target, Ptprv (or ESP), encoding a transmembrane tyrosine phosphatase. Ptprv transcription is dramatically and preferentially increased in cultured cells undergoing p53-dependent cell cycle arrest, but not in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 9,10-Dimethyl-1,2-benzanthracene
Share to Carcinogens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to G1 Phase

Share to Intestinal Mucosa

Share to Intestine, Small

Share to Papilloma

Share to Protein Tyrosine Phosphatases

Source

Open in PubMed Open full text

Identifiers

PMID: 16107883
DOI: 10.1038/sj.emboj.7600769
PMCID: PMC1201350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv.PMID 16107883Read ↗

Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancersSemantic proximity Read ↗

DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model.Semantic proximity Read ↗

Mice Heterozygous for Germ-line Mutations in Methylthioadenosine Phosphorylase ( MTAP ) Die Prematurely of T-Cell LymphomaSemantic proximity Read ↗

The Atypical Cyclin-Like Protein Spy1 Overrides p53-Mediated Tumour Suppression and Promotes Susceptibility to Breast TumorigenesisSemantic proximity Read ↗

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.Semantic proximity Read ↗

High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading.Semantic proximity Read ↗

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.Semantic proximity Read ↗

Rlip depletion prevents spontaneous neoplasia in TP53 null miceSemantic proximity Read ↗

PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen.Semantic proximity Read ↗

Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis.Semantic proximity Read ↗

Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis.Semantic proximity Read ↗

Loss of DNA polymerase zeta enhances spontaneous tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.