Article
A phosphomimetic mutant of RelA/p65 at Ser536 induces apoptosis and senescence: An implication for tumor-suppressive role of Ser536 phosphorylation.
International journal of cancer - 1 Mar 2016
Bu Yiwen, Li Xiaoning, He Yingchun, Huang Chenfei, Shen Yi, Cao Yu, Huang Dan, Cai Chuan, Wang Yuhong, Wang Ziqi, Liao Duan-Fang, Cao Deliang
Abstract excerpt
Hundreds of NF-κB inhibitors have been developed for cancer therapy, but their clinical efficacy is unsatisfactory. Here we show that the phosphorylation activation at Ser536 of RelA/p65 protein, a main subunit in the NF-κB family, may play a tumor-suppressive role. In normal colon mucosa, RelA/p65 phosphorylation at Ser536 was increasingly increased with the maturation and apoptotic shedding of epithelial cells,...
Topics
- Animals
- Apoptosis
- Cell Line, Tumor
- Cellular Senescence
- Colonic Neoplasms
- Humans
- Mice
- Mutation
- Phosphorylation
- Serine
- Transcription Factor RelA