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Article

Deficient cerebral clearance of vasculotropic mutant Dutch/Iowa Double A beta in human A betaPP transgenic mice.

Neurobiology of aging - 1 Jul 2006

Davis Judianne, Xu Feng, Miao Jianting, Previti Mary Lou, Romanov Galina, Ziegler Kelly, Van Nostrand William E

Abstract excerpt

Cerebral amyloid angiopathy (CAA) is a prominent pathological feature of Alzheimer's disease and related familial CAA disorders. However, the mechanisms that account for the cerebral vascular accumulation of amyloid beta-peptide (A beta) have not been defined. Recently, we reported novel transgenic mice (Tg-SwDI) expressing neuronally derived Swedish/Dutch/Iowa vasculotropic mutant human A beta precursor (A...

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PMID: 16105708
DOI: 10.1016/j.neurobiolaging.2005.05.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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