Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations of the SDHB and SDHD genes.

Familial cancer - 1 Jan 2005

Pawlu Christian, Bausch Birke, Neumann Hartmut P H

Abstract excerpt

The succinate dehydrogenase (SDH) is a mitochondrial enzyme complex with an important role in oxydative phosphorylation and intracellular oxygene sensing and signaling. Mutations in the SDHB (1p35-36) and SDHD subunits (11q23) give rise to the paraganglioma syndromes (PGL), namely PGL 4 and PGL 1, and generate paraganglioma and pheochromocytoma. For both genes mutations have been described that result in a loss...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Gland Neoplasms
Share to Head and Neck Neoplasms
Share to Iron-Sulfur Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Paraganglioma

Share to Pheochromocytoma

Share to Protein Subunits

Share to Succinate Dehydrogenase

Source

Identifiers

PMID: 15883710
DOI: 10.1007/s10689-004-4227-4

Genes

SDHD
SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of the SDHB and SDHD genes.PMID 15883710Read ↗

Germline SDHB and SDHD mutations in pheochromocytoma and paraganglioma patientsSemantic proximity Read ↗

15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma–paraganglioma syndromes characterized by germline SDHB and SDHD mutationsSemantic proximity Read ↗

Back to Biochemistry: Evaluation for and Prognostic Significance of SDH Mutations in Paragangliomas and Pheochromocytomas.Semantic proximity Read ↗

Back to Biochemistry: Evaluation for and Prognostic Significance of SDH Mutations in Paragangliomas and Pheochromocytomas.Semantic proximity Read ↗

Epigenetic and metabolic reprogramming of SDH-deficient paragangliomasSemantic proximity Read ↗

SDH mutations in cancer.Semantic proximity Read ↗

Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomasSemantic proximity Read ↗

Research progress on the pathogenesis of the SDHB mutation and related diseases.Semantic proximity Read ↗

SDHA is a tumor suppressor gene causing paraganglioma.Semantic proximity Read ↗

Clinical aspects of SDHx-related pheochromocytoma and paraganglioma.Semantic proximity Read ↗

Succinate dehydrogenase (SDH)‐deficient neoplasiaSemantic proximity Read ↗

Gene of the month: SDH.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.