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Article

Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis.

The Journal of cell biology - 18 Jul 2005

Zhang Xiaoyu, Wang Puyue, Gangar Akanksha, Zhang Jian, Brennwald Patrick, TerBush Daniel, Guo Wei

Abstract excerpt

The tumor suppressor lethal giant larvae (Lgl) plays a critical role in epithelial cell polarization. However, the molecular mechanism by which Lgl carries out its functions is unclear. In this study, we report that the yeast Lgl proteins Sro7p and Sro77p directly interact with Exo84p, which is a component of the exocyst complex that is essential for targeting vesicles to specific sites of the plasma membrane for...

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Identifiers

PMID: 16027223
DOI: 10.1083/jcb.200502055
PMCID: PMC2171422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis.PMID 16027223Read ↗

Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9.Semantic proximity Read ↗

Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis.Semantic proximity Read ↗

Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular function.Semantic proximity Read ↗

Sro7 and Sro77, the yeast homologues of the Drosophila lethal giant larvae (Lgl), regulate cell proliferation via the Rho1-Tor1 pathway.Semantic proximity Read ↗

Sro7p, a Saccharomyces cerevisiae counterpart of the tumor suppressor l(2)gl protein, is related to myosins in function.Semantic proximity Read ↗

Exocyst subunits Exo70 and Exo84 cooperate with small GTPases to regulate behavior and endocytic trafficking in C. elegans.Semantic proximity Read ↗

The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity.Semantic proximity Read ↗

An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components.Semantic proximity Read ↗

Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complex.Semantic proximity Read ↗

Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p.Semantic proximity Read ↗

Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane.Semantic proximity Read ↗

The tomosyn homologue, Sro7, is a direct effector of the Rab GTPase, Sec4, in post-Golgi vesicle tethering.Semantic proximity Read ↗

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