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Article

The GTPase-activating protein Rga1 interacts with Rho3 GTPase and may regulate its function in polarized growth in budding yeast.

PloS one - 1 Jan 2015

He Fei, Nie Wen-Chao, Tong Zongtian, Yuan Si-Min, Gong Ting, Liao Yuan, Bi Erfei, Gao Xiang-Dong

Abstract excerpt

In budding yeast, Rga1 negatively regulates the Rho GTPase Cdc42 by acting as a GTPase-activating protein (GAP) for Cdc42. To gain insight into the function and regulation of Rga1, we overexpressed Rga1 and an N-terminally truncated Rga1-C538 (a.a. 538-1007) segment. Overexpression of Rga1-C538 but not full-length Rga1 severely impaired growth and cell morphology in wild-type cells. We show that Rga1 is...

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PMID: 25860339
DOI: 10.1371/journal.pone.0123326
PMCID: PMC4393305

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Source receipt: pubmed, retrieved 7 Sept 2026.

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