Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9.

Molecular and cellular biology - 1 Jul 2000

Firestein R, Cui X, Huie P, Cleary M L

Abstract excerpt

Mammalian SET domain-containing proteins define a distinctive class of chromatin-associated factors that are targets for growth control signals and oncogenic activation. SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9, contains both SET and chromo domains, signature motifs for proteins that contribute to epigenetic control of gene expression through effects on the regional organization of chromatin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Amino Acid Motifs
Share to G1 Phase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Intracellular Signaling Peptides and Proteins

Share to Methyltransferases

Share to Organelles

Share to S Phase

Source

Open in PubMed Open full text

Identifiers

PMID: 10848615
DOI: 10.1128/MCB.20.13.4900-4909.2000
PMCID: PMC85941

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9.PMID 10848615Read ↗

A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain.Semantic proximity Read ↗

Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

JAK signaling globally counteracts heterochromatic gene silencing.Semantic proximity Read ↗

Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growthSemantic proximity Read ↗

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.Semantic proximity Read ↗

Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart.Semantic proximity Read ↗

Altered telomere homeostasis and resistance to skin carcinogenesis in Suv39h1 transgenic mice.Semantic proximity Read ↗

EVI1 recruits the histone methyltransferase SUV39H1 for transcription repressionSemantic proximity Read ↗

A motif within SET-domain proteins binds single-stranded nucleic acids and transcribed and supercoiled DNAs and can interfere with assembly of nucleosomes.Semantic proximity Read ↗

Unphosphorylated STAT3 in heterochromatin formation and tumor suppression in lung cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.