Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PD.

doi:10.1016/j.parkreldis.2005.05.004

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Article

Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PD.

Parkinsonism & related disorders - 1 Sept 2005

Gosal David, Ross Owen A, Wiley Joe, Irvine G Brent, Johnston Janet A, Toft Mathias, Mata Ignacio F, Kachergus Jennifer, Hulihan Mary, Taylor Julie P, Lincoln Sarah J, Farrer Matthew J, Lynch Timothy, Mark Gibson J

Abstract excerpt

The role of genetics in parkinsonism has been confirmed over the last decade with the identification of genetic variation in seven genes, which are causative in familial forms of the disorder. A number of pathogenic mutations have been identified in the latest gene LRRK2, with a Gly2019Ser amino acid substitution identified in two siblings and one patient with idiopathic Parkinson's disease from Ireland. The...

Topics

Adult
Amino Acid Substitution
Antiparkinson Agents
Cognition
Disease Progression
Functional Laterality
Haplotypes
Humans
Ireland
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Levodopa

Male

Middle Aged

Mutation

Neuropsychological Tests

Parkinson Disease

Protein Serine-Threonine Kinases

Source

Open in PubMed

Identifiers

PMID: 16102999
DOI: 10.1016/j.parkreldis.2005.05.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16102999-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PD.PMID 16102999Read ↗

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