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Article

A combination of mutations enhances the neurotropism of AAV-2.

Virology - 25 Oct 2005

Xu Jianfeng, Ma Chunyan, Bass Caroline, Terwilliger Ernest F

Abstract excerpt

There is strong interest in developing practical strategies for gene delivery to the central nervous system (CNS). Direct delivery into the brain or spinal cord is highly invasive as well as inefficient or hazardous using most current vector systems. Our objective was to generate innocuous gene vehicles that would be effectively taken up by axons and then home to the neuron cell bodies. Vectors derived from...

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Identifiers

PMID: 16102794
DOI: 10.1016/j.virol.2005.06.051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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