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Article

The tyrosine capsid mutations on retrograde adeno-associated virus accelerates gene transduction efficiency.

Molecular brain - 8 Aug 2022

Nakahama Ryota, Saito Aika, Nobe Sensho, Togashi Kazuya, Suzuki Ikuo K, Uematsu Akira, Emoto Kazuo

Abstract excerpt

Adeno-associated virus (AAV) vector is a critical tool for gene delivery through its durable transgene expression and safety profile. Among many serotypes, AAV2-retro is typically utilized for dissecting neural circuits with its retrograde functionality. However, this vector requires a relatively long-term incubation period (over 2 weeks) to obtain enough gene expression levels presumably due to low efficiency in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35941689
DOI: 10.1186/s13041-022-00957-0
PMCID: PMC9358834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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