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Article

Functional analysis of mutations endowing rAAV2-retro with retrograde tracing capacity.

Neuroscience letters - 27 Jul 2022

Zhang Yujing, Wang Jingyi, Li Jiamin, Chen Yefei, Sun Jing, Lu Zhonghua, Li Yuantao, Liu Taian

Abstract excerpt

Recombinant adeno-associated viruses (rAAVs) are widespread vectors in neuroscience research. However, the nearly absent retrograde access to projection neurons hampers their application in functional dissection of neural circuits and in therapeutic intervention. Recently, engineering of the AAV2 capsid has generated an AAV variant, called rAAV2-retro, with exceptional retrograde functionality. This variant...

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PMID: 35718237
DOI: 10.1016/j.neulet.2022.136746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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