Article

Molecular basis of vitamin K-dependent protein γ-glutamyl carboxylation

2025-02-09

Abstract excerpt

Gamma-glutamyl carboxylase (GGCX) in human is the sole enzyme responsible for catalyzing the carboxylation of glutamate (Glu) to γ-carboxyglutamate (Gla), a process that relies on the deprotonation of reduced vitamin K. This post-translational modification of vitamin K-dependent proteins (VKDPs) plays a pivotal role in numerous biological processes. Mutations in GGCX are responsible for multiple clinical phenotype...

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Literature Corpus work: a876db03-bc1d-511c-b84c-2c180c68ec91
DOI: 10.1101/2025.02.09.637231

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