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Article

Vitamin K-dependent coagulation factors deficiency.

Seminars in thrombosis and hemostasis - 1 Jun 2009

Brenner Benjamin, Kuperman Amir A, Watzka Matthias, Oldenburg Johannes

Abstract excerpt

All vitamin K-dependent coagulation factors require normal function of gamma-glutamyl carboxylase and vitamin K epoxide reductase enzyme complex (VKORC1). Heritable dysfunction of gamma-glutamyl carboxylase or of the VKORC1 complex results in the secretion of poorly carboxylated vitamin K-dependent proteins that play a role in coagulation. The following review will summarize the clinical manifestations of vitamin...

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Source

Identifiers

PMID: 19598072
DOI: 10.1055/s-0029-1225766

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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