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Article

Temporal quantitation of mutant Kit tyrosine kinase signaling attenuated by a novel thiophene kinase inhibitor OSI-930.

Molecular cancer therapeutics - 1 Aug 2005

Petti Filippo, Thelemann April, Kahler Jen, McCormack Siobhan, Castaldo Linda, Hunt Tony, Nuwaysir Lydia, Zeiske Lynn, Haack Herbert, Sullivan Laura, Garton Andrew, Haley John D

Abstract excerpt

OSI-930, a potent thiophene inhibitor of the Kit, KDR, and platelet-derived growth factor receptor tyrosine kinases, was used to selectively inhibit tyrosine phosphorylation downstream of juxtamembrane mutant Kit in the mast cell leukemia line HMC-1. Inhibition of Kit kinase activity resulted in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16093434
DOI: 10.1158/1535-7163.MCT-05-0114

Genes

KDR
PSTPIP2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16093434-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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