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Article

Phosphoflow-Based Evaluation of Mek Inhibitors as Small-Molecule Therapeutics for B-Cell Precursor Acute Lymphoblastic Leukemia.

PloS one - 1 Jan 2015

George Aswathi A, Paz Helicia, Fei Fei, Kirzner Jonathan, Kim Yong-Mi, Heisterkamp Nora, Abdel-Azim Hisham

Abstract excerpt

Upstream mutations that lead to constitutive activation of Erk in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are relatively common. In the era of personalized medicine, flow cytometry could be used as a rapid method for selection of optimal therapies, which may include drugs that target the Erk pathway. Here, we evaluated the utility of phospho-flow, compared to Western blotting, to monitor Erk...

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Identifiers

PMID: 26360058
DOI: 10.1371/journal.pone.0137917
PMCID: PMC4567297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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