Article
Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells.
Stem cells translational medicine - 1 Aug 2016
Jackson Melany, Ma Rui, Taylor A Helen, Axton Richard A, Easterbrook Jennifer, Kydonaki Maria, Olivier Emmanuel, Marenah Lamin, Stanley Edouard G, Elefanty Andrew G, Mountford Joanne C, Forrester Lesley M
Abstract excerpt
UNLABELLED: : We have developed a robust, Good Manufacturing Practice-compatible differentiation protocol capable of producing scalable quantities of red blood cells (RBCs) from human pluripotent stem cells (hPSCs). However, translation of this protocol to the clinic has been compromised because the RBCs produced are not fully mature; thus, they express embryonic and fetal, rather than adult globins, and they do...
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