Article
Uptake of lead and iron by divalent metal transporter 1 in yeast and mammalian cells.
Biochemical and biophysical research communications - 26 Jul 2002
I Bannon Desmond, Portnoy Matthew E, Olivi Luisa, Lees Peter S J, Culotta Valeria C, Bressler Joseph P
Abstract excerpt
Although the divalent metal transporter (DMT1) was suggested to transport a wide range of metals in Xenopus oocytes, recent studies in other models have provided contrasting results. Here, we provide direct evidence demonstrating that DMT1 expressed in yeast mutants defective for high affinity iron transport facilitates the transport of iron with an 'apparent K(m)' of approximately 1.2 microM, and transport of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.